How U.S. Cannabis Policy Affects Ghana's Emerging Medical Cannabis Sector

Bye-Bye 280E: How Cannabis Rescheduling Will Transform the Industry

Update Historic Shift: Understanding the Executive OrderOn December 18, 2025, President Trump signed a groundbreaking executive order titled “Increasing Medical Marijuana and Cannabidiol Research,” aimed at redirecting the federal stance on cannabis. This directive mandates Attorney General Pam Bondi to initiate the complex process of rescheduling marijuana from its current classification as a Schedule I drug to Schedule III under the Controlled Substances Act. Currently, with marijuana deemed a Schedule I substance, it has been categorized alongside drugs like heroin and LSD, which implies a high potential for abuse and no accepted medical use. The implications of this order are profound and set the stage for monumental changes within the cannabis industry.The Impending End of Section 280EAmong the most significant consequences of rescheduling cannabis is the anticipated elimination of the constraints imposed by Section 280E of the Internal Revenue Code. For years, cannabis businesses have suffered under this provision, which prohibits any deduction for ordinary business expenses when operating within federally classified illegal substances. As a result, cannabis operators have faced higher effective tax rates than companies in other industries. Take an example where both cannabis and traditional businesses generate the same revenue of $1 million but incur $650,000 in cost of goods sold and $250,000 in expenses. Under Section 280E, the cannabis business pays taxes on a gross income of $350,000, leading to heavy financial losses, while the traditional business can deduct its expenses and only pay tax on its net income. Rescheduling to Schedule III would enable cannabis operators to deduct these essential business expenses, leveling the financial playing field.Broader Financial and Tax BenefitsThe rescheduling process is expected to breathe new life into the financial landscape of the cannabis industry. Banks, payment processors, and insurers previously hesitant to engage with cannabis businesses are likely to revisit these opportunities, opening doors to improved access to capital through loans and credit. In a post-rescheduling era, companies will also stand to benefit from expanded insurance options and an overall reduced cost of borrowing. As Karan Wadera of Casa Verde Capital stated, this executive action could mark a significant inflection point for the U.S. cannabis sector, reshaping cash flows, balance sheets, and overall business valuation.Tax Credits and Research OpportunitiesWith the removal of the 280E prohibition, cannabis companies will be better positioned to leverage federal tax credits, including those related to research and development (R&D). This adjustment encourages industry participants to invest in domestic R&D, spurring innovation and job creation. As highlighted by industry experts, the ability to deduct ordinary business expenses stands to reduce the accepted tax liability, incentivizing further investment and growth in the cannabis sector. The potential for R&D advancements could play a crucial role in shaping the future of medical marijuana and its therapeutic benefits.What Lies Ahead: Navigating ChangesAlthough the executive order marks a pivotal moment, it’s essential to remember that the rescheduling process remains complex and will involve additional steps by the Department of Health and Human Services, the Department of Justice, and the Drug Enforcement Administration. Given the historical challenges in cannabis policy shifts, both operators and investors should adopt a proactive approach in preparing for these upcoming changes. Conducting regular assessments of tax structures, financing options, and operational readiness will be critical for capturing the new opportunities presented by a post-280E environment.Conclusion: A New Era for Cannabis BusinessesThis executive order signals more than just a bureaucratic shift; it heralds the dawn of significant financial reform for cannabis businesses across the nation. As the rescheduling process unfolds, now is the time for operators, investors, and stakeholders to strategize and optimize their positions in anticipation of a transformed landscape where cannabis can thrive under fairer fiscal policies. Keep a close eye on developments and prepare to adapt to the evolving opportunities within the cannabis industry.